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microvascular endothelial cell line as m5  (PromoCell)


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    PromoCell microvascular endothelial cell line as m5
    Tumor growth and tumor response to radiation therapy critically depend on endothelial Cav1 expression. Syngeneic MPR xenografts implanted into Cav1-deficient C57Bl/6 mice grew faster and displayed less integration of smooth muscle cells into the wall of newly formed blood vessels indicative for a less stabilized vessel phenotype compared with tumors from Cav1 wild-type animals. High Cav1 expression in ECs protected vascular structures from radiation-induced damage at a clinically relevant dose, resulting in a decreased tumor growth delay upon irradiation. In contrast, the loss of stromal Cav1 increased the sensitivity of ECs to radiation-induced apoptosis thereby enhancing tumor growth delay upon radiotherapy. Thus, Cav1 content of vascular cells determines the sensitivity to <t>microvascular</t> damage and is critical for the regulation of the tumor response to radiation. Thus, the pro-survival factor Cav1 might be a promising therapeutic target for combinatorial therapies to counteract radiation resistance of prostate cancer at the level of the tumor vasculature.
    Microvascular Endothelial Cell Line As M5, supplied by PromoCell, used in various techniques. Bioz Stars score: 99/100, based on 2482 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/microvascular endothelial cell line as m5/product/PromoCell
    Average 99 stars, based on 2482 article reviews
    microvascular endothelial cell line as m5 - by Bioz Stars, 2026-03
    99/100 stars

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    1) Product Images from "Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors"

    Article Title: Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors

    Journal: Oncogenesis

    doi: 10.1038/oncsis.2015.9

    Tumor growth and tumor response to radiation therapy critically depend on endothelial Cav1 expression. Syngeneic MPR xenografts implanted into Cav1-deficient C57Bl/6 mice grew faster and displayed less integration of smooth muscle cells into the wall of newly formed blood vessels indicative for a less stabilized vessel phenotype compared with tumors from Cav1 wild-type animals. High Cav1 expression in ECs protected vascular structures from radiation-induced damage at a clinically relevant dose, resulting in a decreased tumor growth delay upon irradiation. In contrast, the loss of stromal Cav1 increased the sensitivity of ECs to radiation-induced apoptosis thereby enhancing tumor growth delay upon radiotherapy. Thus, Cav1 content of vascular cells determines the sensitivity to microvascular damage and is critical for the regulation of the tumor response to radiation. Thus, the pro-survival factor Cav1 might be a promising therapeutic target for combinatorial therapies to counteract radiation resistance of prostate cancer at the level of the tumor vasculature.
    Figure Legend Snippet: Tumor growth and tumor response to radiation therapy critically depend on endothelial Cav1 expression. Syngeneic MPR xenografts implanted into Cav1-deficient C57Bl/6 mice grew faster and displayed less integration of smooth muscle cells into the wall of newly formed blood vessels indicative for a less stabilized vessel phenotype compared with tumors from Cav1 wild-type animals. High Cav1 expression in ECs protected vascular structures from radiation-induced damage at a clinically relevant dose, resulting in a decreased tumor growth delay upon irradiation. In contrast, the loss of stromal Cav1 increased the sensitivity of ECs to radiation-induced apoptosis thereby enhancing tumor growth delay upon radiotherapy. Thus, Cav1 content of vascular cells determines the sensitivity to microvascular damage and is critical for the regulation of the tumor response to radiation. Thus, the pro-survival factor Cav1 might be a promising therapeutic target for combinatorial therapies to counteract radiation resistance of prostate cancer at the level of the tumor vasculature.

    Techniques Used: Expressing, Irradiation



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    microvascular endothelial cell line as m5  (PromoCell)
    99
    PromoCell microvascular endothelial cell line as m5
    Tumor growth and tumor response to radiation therapy critically depend on endothelial Cav1 expression. Syngeneic MPR xenografts implanted into Cav1-deficient C57Bl/6 mice grew faster and displayed less integration of smooth muscle cells into the wall of newly formed blood vessels indicative for a less stabilized vessel phenotype compared with tumors from Cav1 wild-type animals. High Cav1 expression in ECs protected vascular structures from radiation-induced damage at a clinically relevant dose, resulting in a decreased tumor growth delay upon irradiation. In contrast, the loss of stromal Cav1 increased the sensitivity of ECs to radiation-induced apoptosis thereby enhancing tumor growth delay upon radiotherapy. Thus, Cav1 content of vascular cells determines the sensitivity to <t>microvascular</t> damage and is critical for the regulation of the tumor response to radiation. Thus, the pro-survival factor Cav1 might be a promising therapeutic target for combinatorial therapies to counteract radiation resistance of prostate cancer at the level of the tumor vasculature.
    Microvascular Endothelial Cell Line As M5, supplied by PromoCell, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/microvascular endothelial cell line as m5/product/PromoCell
    Average 99 stars, based on 1 article reviews
    microvascular endothelial cell line as m5 - by Bioz Stars, 2026-03
    99/100 stars
    		  Buy from Supplier

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    Tumor growth and tumor response to radiation therapy critically depend on endothelial Cav1 expression. Syngeneic MPR xenografts implanted into Cav1-deficient C57Bl/6 mice grew faster and displayed less integration of smooth muscle cells into the wall of newly formed blood vessels indicative for a less stabilized vessel phenotype compared with tumors from Cav1 wild-type animals. High Cav1 expression in ECs protected vascular structures from radiation-induced damage at a clinically relevant dose, resulting in a decreased tumor growth delay upon irradiation. In contrast, the loss of stromal Cav1 increased the sensitivity of ECs to radiation-induced apoptosis thereby enhancing tumor growth delay upon radiotherapy. Thus, Cav1 content of vascular cells determines the sensitivity to microvascular damage and is critical for the regulation of the tumor response to radiation. Thus, the pro-survival factor Cav1 might be a promising therapeutic target for combinatorial therapies to counteract radiation resistance of prostate cancer at the level of the tumor vasculature.

    Journal: Oncogenesis

    Article Title: Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors

    doi: 10.1038/oncsis.2015.9

    Figure Lengend Snippet: Tumor growth and tumor response to radiation therapy critically depend on endothelial Cav1 expression. Syngeneic MPR xenografts implanted into Cav1-deficient C57Bl/6 mice grew faster and displayed less integration of smooth muscle cells into the wall of newly formed blood vessels indicative for a less stabilized vessel phenotype compared with tumors from Cav1 wild-type animals. High Cav1 expression in ECs protected vascular structures from radiation-induced damage at a clinically relevant dose, resulting in a decreased tumor growth delay upon irradiation. In contrast, the loss of stromal Cav1 increased the sensitivity of ECs to radiation-induced apoptosis thereby enhancing tumor growth delay upon radiotherapy. Thus, Cav1 content of vascular cells determines the sensitivity to microvascular damage and is critical for the regulation of the tumor response to radiation. Thus, the pro-survival factor Cav1 might be a promising therapeutic target for combinatorial therapies to counteract radiation resistance of prostate cancer at the level of the tumor vasculature.

    Article Snippet: The human microvascular endothelial cell line AS-M5 was cultured in ECG medium (PromoCell).

    Techniques: Expressing, Irradiation